GATTERMANN KOCH REACTION MECHANISM PDF

Summary What is Gattermann Reaction? Gattermann reaction is an organic substitution reaction in which we can formylate aromatic compounds. It is named after the German chemist Ludwig Gattermann. Further, this reaction can take place in the presence of Lewis acid catalysts. The Lewis acid catalyst we use mostly is AlCl3.

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In the second step, oxidation of this toluene molecule by potassium permanganate followed by acidic hydrolysis ,produced the expected benzoic acid. There are many other methods for the preparation of benzoic acid from benzene molecule. In the first step, benzene reacts with bromine in presence of iron catalyst , it form bromo benzene. This bromo benzene reacts with metallic magnesium in dry ether medium , changed into Grignard reagent , phenyl magnesium bromide. Finally, phenyl magnesium bromide reacts with carbon dioxide followed by hydrolysis , gives the expected product , benzoic acid.

Again , benzoic acid can be prepared from benzene , converting it acetophenone in the first step by Friedel craft acylation. The acidic hydrolysis of this sodium benzoate gives benzoic acid. One more change of benzene to benzoic acid through nitration of benzene.

Nitration of benzene, followed by reduction , gives aniline. This aniline under goes diazotization reaction to form diazonium salt. Gattermann-Koch reaction. Besides the above reactions, the another most important name reaction ,Gattermann-Koch aldehyde synthesis ,through which benzoic acid may be prepared. When a mixture of carbon monoxide and hydrogen chloride is passed through benzene solution in presence of anhydrous AlCl3 and little amount of Cu2Cl2 catalyst , then benzaldehyde is obtained as the main product.

This reaction is known as Gattermann-Koch aldehyde synthesis. The solvent used in this reaction is nitrobenzene or ether. On oxidization of this benzaldehyde by oxidizing agent ,the expected benzoic acid is obtained. Summary: Benzene to benzoic acid-Gattermann-Koch reaction. Benzene to benzoic acid change.

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Gattermann-Synthese

Weitergeleitet von Gattermann-Koch-Synthese Bei der Gattermann-Synthese handelt es sich um eine Namensreaktion in der Organischen Chemie , die verwendet wird, um aromatische Aldehyde aus Phenolen oder anderen Aromaten zu synthetisieren. Benannt wurde sie nach dem Goslarer Chemiker Ludwig Gattermann. Die Gattermann-Synthese kann auch eingesetzt werden, um einzelne Kohlenwasserstoffverbindungen , Heterocyclen wie Furan -, Pyrrol - und Indolderivate sowie Thiophen zu synthetisieren. Mechanismus Bei der Gattermann-Reaktion handelt es sich um eine Elektrophile aromatische Substitution. Dieses wird durch Deprotonierung rearomatisiert. Durch Hydrolyse entsteht der formylierte Aromat.

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